Tired of all those medical tests to find out what your suffering from? Often they inconclusive requiring more tests, or wrong a diagnosis. Well all that may soon change as tests are on the way that can very quickly detect tiny amounts of protein in blood, or other body fluids, that indicate diseases, and display them barcode fashion.
As reported in Discover magazine, they created tiny gold nano-particles — hundreds of thousands of time smaller than the width of a human hair. When the particles are released in a blood, urine, or saliva sample taken from a patient, the genetic material latches on to any disease proteins they find. Proteins, the building blocks of living things, can serve as fingerprints for diseases.
"The nano-particle is coded with many strands of DNA which are identical, which are the barcodes," Mirkin explains. "When the nano-particle binds to the protein target of interest, it releases these mini barcodes for every protein molecule that is in solution, so that you're getting amplification," allowing the researchers to easily scan for disease with currently available DNA detection techniques.
"We have a chip that has many different spots of DNA on it that are designed to recognize all of the possible barcodes that are in the mixture," Mirkin says. "It binds the right spot and provides a signal that can be easily read with a screener."
Interesting to say the least. Maybe being six orders of magnitude more sensitive than any current tests, I wonder if it can find the HIV virus that is so elusive now except by in vitro methods.
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